In Asia, futures tip Japanese equities to open down. Nikkei futures in Chicago were off by 0.22 percent at 20,180 and Osaka futures were lower by 0.37 percent at 6:30 a.m. HK/SIN, compared with the Nikkei 225‘s Tuesday close of 20,225.09.

Australian stocks also looked set for a lower open. SPI futures were down 1.26 percent at 5,642 against the S&P/ASX 200‘s last close of 5,714.194.

Markets in Indonesia are closed until the end of the week.

U.S. stocks closed lower on Wall Street following the Senate’s decision to postpone voting on a new health-care bill. Technology stocks also fared poorly, with Alphabet falling by more than 2 percent. The EU fined Alphabet unit Google a record $2.7 billion, as regulators ruled the company violated antitrust rules.

The Dow Jones industrial average declined 0.46 percent, or 98.89 points, to close at 21,310.66, the S&P 500 fell 0.81 percent, or 19.69 points, to end at 2,419.38, and the Nasdaq tumbled 1.61 percent to finish at 6,146.62.

Oil prices gained almost 2 percent overnight to hit a one-week high on Tuesday. Brent crude rose 1.79 percent to settle at $46.65 a barrel and U.S. crude settled up 1.98 percent at $44.24.

In currencies, the dollar index, which tracks the dollar against a basket of rival currencies, tumbled to trade at 96.394. This was lower than the 97 handle seen for the last two weeks. The greenback also ceded ground after hitting a five-week high against the yen earlier in the session. The dollar/yen traded at 112.22 at 7:14 a.m. HK/SIN.

— CNBC’s Dan Mangan and Kayla Tausche contributed to this report.